BENEFIT-RISK EVALUATION OF MAMMOGRAPHIC MASS SCREENING

Mammographic screening of women aged 40-49 years. Benefit, risk, and cost considerations.

A recently published meta-analysis of seven randomized trials showed a statistically significant 24% reduction in mortality rate with the use of mammographic screening for women age 40-49 years. The benefit would have been even greater if screening had been performed at shorter annual intervals with the most up-to-date mammographic equipment. Additionally, these trials underestimated benefit du...

Risk of radiation-induced breast cancer from mammographic screening.

PURPOSE To assess a schema for estimating the risk of radiation-induced breast cancer following exposure of the breast to ionizing radiation as would occur with mammography and to provide data that can be used to estimate the potential number of breast cancers, cancer deaths, and woman-years of life lost attributable to radiation exposure delivered according to a variety of screening scenarios....

Overdiagnosis in Mammographic Screening because of Competing Risk of Death.

BACKGROUND Different definitions and estimates of overdiagnosis in mammographic screening reflect a substantial need to investigate and understand the complexity of the issue. This modeling study aims to estimate the number of overdiagnosed women, defined as those diagnosed with breast cancer who die from any cause within the lead-time period. METHODS We used numbers from incidence and death ...

Mammographic screening and risk factors for breast cancer.

Screening mammography can distort estimated effects in breast cancer risk models due to associations with other risk factors. Mammography information was available in the Nurses' Health Study from 1988, and 1,815 incident breast cancers were accrued through 2000 among 55,625 women with risk factor data. Logistic models were fit for screening mammography, and inverse probability weighting was us...

Improving rates of mammographic screening.